Indirect regulation of gene expression

• Fragile Histidine Triad (FHIT) Gene and Its Association with p53 Protein Expression in the Progression of Gall Bladder Cancer

Cancer Investigation 27:7, 764 – 773 2009

Priya, T. Padma , Kapoor, V. K. , Krishnani, Narendra , Agrawal, Vinita and Agarwal, Suraksha

Abstract

Objective:
Present study deals with LOH and MSI in FHIT gene and p53 expression in GBC, CC, XGC, and normal GB to elucidate the role of FHIT gene in gall bladder cancer.

Methods:
Five microsatellite markers D3S1217, D3S1300, D3S1313, D3S1600, and D3S2757, were selected.

Results:
Among GBC cases the frequency of MSI-H and LOH was 17.5% and 27.5%, respectively. Significant difference was found between GBC and normal GB (p = .02), and GBC and CC groups (p= .002) when LOH was compared.

Conclusion:
Our results suggested CC might act as a preinvasive stage in the pathogenesis of GBC.

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